Once the self proclaimed poster girl for mental illness, Ruby Wax has evolved her stand up act, because, as she puts it, “everyone has mental illness now. It spread like wildfire.”

It’s a tongue in cheek reference to the current supposed "fashion" for speaking up and out about mental health with the aim to de-stigmatise and taboo-bust – something that Wax has contributed hugely to over the years, by bravely opening up about her own journey to let other people know that it was OK to not be OK.

Taking place at the Theatre Royal, Andy Hamilton’s show is entitled An Evening with… rather than a straight stand-up and mainly consists of the comedy writer/performer and gameshow regular answering audience questions. During the first half this is done via raising a hand and shouting out questions; during the second half by leaving pieces of paper on the stage front during the interval.

Let's start with that kiss – the one that propelled Seann Walsh from “Who?” in last year's Strictly Come Dancing line-up to being the “bad boy” of the series after pictures of his drunken late-night clinch with Katya Jones, his married professional dance partner, appeared in the tabloids.

Reginald D Hunter drops the n-bomb near the top of the show. He means no offence, he tells the audience, but it's the vernacular where he comes from in Georgia. And besides, using that word, as well as expressing some trenchant opinions about the differences between men and women, and the politics of race, has sort of become Hunter's calling card.

The Komedia is a Brighton Institution and celebrates its birthday tonight in a suitably raucous fashion. The Komedia began in 1994, founded by the directors of the Umbrella Theatre Company, and styled on the cabaret spaces they’d experienced touring Europe. It moved to its current premises in 1999, turning a ramshackle labyrinthine building that housed a hippy-style market (before that a Tesco) into a labyrinthine building housing a bar-venue-cinema complex, with the central hub in the large basement.

Mark Thomas issues a health warning for Check-Up: Our NHS at 70  at Battersea Arts Centre  – “This show contains swearing, a video of an operation on a stomach and a description of being in A&E when a patient dies.” Indeed it does, but it also contains a heartfelt love letter to the health service Thomas was born in and, as a lifelong socialist, hopes to die in. But as he points to creeping commercialisation, what are the chances of that being so?

A brain tumour isn't usually the subject of a comedy show but Britney, written and performed by comedy duo Charly Clive and Ellen Robertson, is just that. It's “the true story of what happens to two best friends when one of them [Clive] gets a brain tumour” – the size of a golf ball, her father helpfully pointed out.

Tommy Tiernan is something of an institution in his native Ireland, as a stand-up comic, newspaper columnist, sometime chat show host and full-time controversialist. Now his appearance as Da Gerry in Channel 4's Derry Girls has brought him to a wider audience – both geographically and generationally – and deservedly so.

Angela Barnes is one of life’s pessimists, she tells us at the top of the hour, but she’s trying not to be so world-weary, and to turn negatives into positives. And, while there’s so much awfulness going on around us, why not try to lighten the mood a little?

Most people in the UK know American actor and stand-up Aziz Ansari from Parks and Recreation, where he played the sarcastic and underachieving local government official Tom Haverford. Comedy fans will also know him as a successful club comic on both US coasts, and from his Netflix specials.